Enantioselective synthesis of SSR 241586 by using an organo-catalyzed Henry reaction

  • Org Lett. 2010 Aug 20;12(16):3693-5. doi: 10.1021/ol101555g.
Anne Cochi  1 ,  Thomas-Xavier Métro ,  Domingo Gomez Pardo ,  Janine Cossy
Affiliations
  • 1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
PMID: 20666443 DOI: 10.1021/ol101555g
Abstract

An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).

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