Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines
- Eur J Med Chem. 2010 Nov;45(11):5208-16. doi: 10.1016/j.ejmech.2010.08.035.
Affiliations
- 1. Organic Chemistry Division-II, Indian Institute of Chemical Technology, Tarnaka-uppal road, Tarnaka, Hyderabad 500607, India.
PMID: 20832916
DOI: 10.1016/j.ejmech.2010.08.035
Abstract
Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four Cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.