Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus

  • J Nat Prod. 2011 Apr 25;74(4):739-43. doi: 10.1021/np1008009.
Simon P B Ovenden  1 ,  Jonathan L Nielson ,  Catherine H Liptrot ,  Richard H Willis ,  Anthony D Wright ,  Cherie A Motti ,  Dianne M Tapiolas
Affiliations
  • 1. Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia.
PMID: 21348445 DOI: 10.1021/np1008009
Abstract

Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosusols A-D (3-6) and comosone A (7). The structures of all isolated compounds were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values. The cytotoxic activity of all compounds was investigated against a panel of human tumor and mammalian cell lines. These assays found eight of the nine compounds had GI(50) values in the 8-63 μM range.