Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells

  • J Enzyme Inhib Med Chem. 2012 Aug;27(4):490-4. doi: 10.3109/14756366.2011.598151.
Jeong Seon Yoon  1 ,  Eun Ju Jeong ,  Hyekyung Yang ,  Seung Hyun Kim ,  Sang Hyun Sung ,  Young Choong Kim
Affiliations
  • 1. College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
PMID: 21827366 DOI: 10.3109/14756366.2011.598151
Abstract

The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated Alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.

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