Novel microbial transformation of resibufogenin by Fusarium solani

  • J Asian Nat Prod Res. 2011 Sep;13(9):831-7. doi: 10.1080/10286020.2011.597385.
Xiu-Lan Xin  1 ,  Dong-hai Su ,  Deng Sa ,  Yan Tian ,  Bao-Jing Zhang ,  Xiao-Chi Ma ,  Lei An ,  Shan-Shan Huang ,  Ji-Hong Yao ,  Xun Cui
Affiliations
  • 1. Biotechnology Application Center, Beijing Vocational College of Electronic Science and Technology, Beijing 100029, China.
PMID: 21830888 DOI: 10.1080/10286020.2011.597385
Abstract

In this paper, microbial transformation of resibufogenin by Fusarium solani AS 3.1829 was investigated, and five transformed products were isolated and identified as 3-ketone-resibufogenin (2), 3-one-cyclic 3-(1,2-dimethyl-1,2-ethanediylacetal)-resibufogenin (3), 3-dimethoxyl-resibufogenin (4), 3-epi-resibufogenin (5), and 3-epi-15α-hydroxy-7βH-bufalin (6), respectively. Among them, 3, 4, and 6 are new compounds, and the rare double oxidization of C-3 was reported. In addition, the cytotoxicities of transformed products were also investigated.

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