Bioactive A-type proanthocyanidins from Cinnamomum cassia

  • J Nat Prod. 2011 Sep 23;74(9):1833-41. doi: 10.1021/np1007944.
K Brian Killday  1 ,  Matthew H Davey ,  Jan A Glinski ,  Penggao Duan ,  Ravikanth Veluri ,  Gloria Proni ,  F Joseph Daugherty ,  Michael S Tempesta
Affiliations
  • 1. Bruker Biospin Corporation, Billerica, Massachusetts 01821, United States.
PMID: 21875098 DOI: 10.1021/np1007944
Abstract

Two trimeric proanthocyanidins, cinnamtannin B-1 (1) and cinnamtannin D-1 (2), have been isolated from the bark of Cinnamomum Cassia along with the known tetramer parameritannin A-1 (3) and a previously unreported tetramer, named cassiatannin A (4). The structures of 1-4 were elucidated on the basis of 1D and 2D NMR, MS, and CD analyses and compared to the reported data. Proanthocyanidins (1-4) possess significant in vitro inhibitory activity against cyclooxygenase-2 (COX-2) at micromolar concentrations.

Products