Sinularosides A and B, bioactive 9,11-secosteroidal glycosides from the South China Sea soft coral Sinularia humilis Ofwegen

  • J Nat Prod. 2012 Sep 28;75(9):1656-9. doi: 10.1021/np300475d.
Peng Sun  1 ,  Li-Yuan Meng ,  Hua Tang ,  Bao-Shu Liu ,  Ling Li ,  Yanghua Yi ,  Wen Zhang
Affiliations
  • 1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, People's Republic of China.
PMID: 22946634 DOI: 10.1021/np300475d
Abstract

Two new 9,11-secosteroidal glycosides, namely, sinularosides A and B (1, 2), together with the known pregnene glycoside 3β-(β-xylopyranosyloxy)-5α-pregna-20-ene (3), were isolated from the South China Sea soft coral Sinularia humilis Ofwegen. The structures of these compounds were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. This is the first report of 9,11-secosteroidal glycosides from a soft coral and from nature. In in vitro bioassays, the new compounds exhibited potent antimicrobial activities and showed no growth inhibition activity against the tumor cells HepG2 and Caco-2.