Reengineered epipodophyllotoxin

  • Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k.
Igor V Magedov  1 ,  Nikolai M Evdokimov ,  Menuka Karki ,  Amanda S Peretti ,  Dustin T Lima ,  Liliya V Frolova ,  Mary R Reisenauer ,  Anntherese E Romero ,  Paul Tongwa ,  Alexandr Fonari ,  Jeff Altig ,  Snezna Rogelj ,  Mikhail Yu Antipin ,  Charles B Shuster ,  Alexander Kornienko
Affiliations
  • 1. Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA. [email protected]
PMID: 22986348 DOI: 10.1039/c2cc35044k
Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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