Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp

  • J Nat Prod. 2012 Oct 26;75(10):1806-9. doi: 10.1021/np300380t.
Gavin Carr  1 ,  Emily R Derbyshire ,  Eric Caldera ,  Cameron R Currie ,  Jon Clardy
Affiliations
  • 1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
PMID: 23025282 DOI: 10.1021/np300380t
Abstract

Three new members of the angucycline class of Antibiotics, pseudonocardones A-C (1-3), along with the known Antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed Antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.