Novel CD20 monoclonal antibodies for lymphoma therapy

  • J Hematol Oncol. 2012 Oct 11:5:64. doi: 10.1186/1756-8722-5-64.
Shundong Cang  1 ,  Nikhil Mukhi ,  Kemeng Wang ,  Delong Liu
Affiliations
  • 1. Department of Oncology, People’s Hospital, Henan Province, China.
PMID: 23057966 DOI: 10.1186/1756-8722-5-64
Abstract

Rituximab (RTX), a monoclonal antibody (mAb) against CD20, has been widely used for lymphoma therapy. RTX in combination with cyclophosphamide /doxorubicin /vincristine /prednisone (R-CHOP) remains the standard frontline regimen for diffuse large B-cell lymphoma. However, suboptimal response and /or resistance to rituximab have remained a challenge in the therapy of B-cell non-Hodgkin's lymphoma (NHL). Novel agents are under active clinical trials. This review will summarize the latest development in new mAbs against CD20, which include second-generation mAbs, ofatumumab, veltuzumab (IMMU-106), ocrelizumab (PRO70769), and third-generation mAbs, AME-133v (ocaratuzumab), PRO131921 and GA101 (obinutumumab).

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