Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa

  • Fitoterapia. 2013 Sep;89:1-7. doi: 10.1016/j.fitote.2013.04.007.
Xiao-Xia Wang  1 ,  Ke Zan ,  She-Po Shi ,  Ke-Wu Zeng ,  Yong Jiang ,  Yan Guan ,  Chun-Ling Xiao ,  Hui-Yuan Gao ,  Li-Jun Wu ,  Peng-Fei Tu
Affiliations
  • 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
PMID: 23651559 DOI: 10.1016/j.fitote.2013.04.007
Abstract

Five new quinolone Alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their Antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate Antibacterial activities (MIC values: 4-128 μg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 μM).

Keywords
Antibacterial activity; Cytotoxic activity; Evodia rutaecarpa; Quinolone alkaloids.
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