Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts

  • Bioorg Med Chem Lett. 2014 Feb 1;24(3):742-5. doi: 10.1016/j.bmcl.2013.12.110.
Seon-Yeong Kwak  1 ,  Jin-Mi Noh  2 ,  Suyeon Lee  3 ,  So Hun Lee  3 ,  Su-ji Jeon  1 ,  Hye-In Kim  1 ,  Jong-Ho Kim  4 ,  Yoon-Sik Lee  5
Affiliations
  • 1. Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.
  • 2. School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
  • 3. R&D Center, Bioland Ltd., Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
  • 4. Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea. Electronic address: [email protected].
  • 5. School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea. Electronic address: [email protected].
PMID: 24411126 DOI: 10.1016/j.bmcl.2013.12.110
Abstract

Regulation of Collagen synthesis and Matrix Metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, α-Resorcylic acid-phenylalanine amide (α-RA-F) was prepared and its biological activities were observed. We found that α-RA-F boosted Collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity.

Keywords
Collagen synthesis; Resorcylic acid derivative; Suppression of MMPs expression.
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