Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor

  • Bioorg Med Chem Lett. 2014 Dec 15;24(24):5652-5655. doi: 10.1016/j.bmcl.2014.10.080.
Giulio Vistoli  1 ,  Andrea Brizzolari  2 ,  Elena Faioni  3 ,  Cristina Razzari  4 ,  Enzo Santaniello  5
Affiliations
  • 1. Department of Pharmaceutical Science, Università degli Studi, Via Celoria 2, 20100 Milano, Italy.
  • 2. Department of Health Sciences, Università degli Studi, Via A. Di Rudinì 8, 20142 Milano, Italy.
  • 3. Department of Health Sciences, Università degli Studi, Via A. Di Rudinì 8, 20142 Milano, Italy; S. Paolo Hospital, Via A. Di Rudinì 8, 20142 Milano, Italy.
  • 4. S. Paolo Hospital, Via A. Di Rudinì 8, 20142 Milano, Italy.
  • 5. Department of Health Sciences, Università degli Studi, Via A. Di Rudinì 8, 20142 Milano, Italy. Electronic address: [email protected].
PMID: 25467153 DOI: 10.1016/j.bmcl.2014.10.080
Abstract

A few naturally occurring N(6)-substituted adenosine derivatives (Cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by Collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 Receptor binding site.

Keywords
Anti-aggregation activity; Cytokinin ribosides; Homology modeling; Molecular docking; P2Y(12) receptor; Platelets.
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