Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion

  • Molecules. 2014 Dec 4;19(12):20340-9. doi: 10.3390/molecules191220340.
Myoung-Jun Jang  1 ,  Ye Sol Kim  2 ,  Eun Young Bae  3 ,  Tae-Seok Oh  4 ,  Hwa-Jung Choi  5 ,  Jung-Hee Lee  6 ,  Hyun-Mee Oh  7 ,  Seung Woong Lee  8
Affiliations
  • 1. Enviromental Agriculture Research Division, Gyeonggido Agricultural Reaearch and Extension Services(GARES), Hwaseong, Gyeonggi-do 445-784, Korea. [email protected].
  • 2. Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea. [email protected].
  • 3. LINC project group, University Industry Cooperation, Daejeon University, Daejeon 300-716, Korea. [email protected].
  • 4. Department of Plant Resources, Kongju National University, Yesan 340-702, Korea. [email protected].
  • 5. Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea. [email protected].
  • 6. Department of Beauty Science, Kwangju Women's University, Gwangju 506-713, Korea. [email protected].
  • 7. Bioindustial Process Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, Jeollabuk-do 580-185, Korea. [email protected].
  • 8. Department of Chemistry, Mokwon University, Daejeon 302-729, Korea. [email protected].
PMID: 25486247 DOI: 10.3390/molecules191220340
Abstract

Three saikosaponins were isolated from the MeOH extract of the roots of Bupleurum falcatum L.: saikosaponins B3 (1); B4 (2); and D (3). Of the three, compound 3 inhibited the interaction of selectins (E, L, and P) and THP-1 cells with IC50 values of 1.8, 3.0 and 4.3 µM, respectively. Also, the aglycone structure 4 of compound 3 showed moderate inhibitory activity on L-selectin-mediated cell adhesion. From these results, we suspect that compound 3 isolated from Bupleurum falcatum roots would be a good candidate for therapeutic strategies to treat inflammation.

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