Two new lignans from twigs of Aglaia odorata

  • J Asian Nat Prod Res. 2016;18(2):147-52. doi: 10.1080/10286020.2015.1057575.
Lei Peng  1  2 ,  Wu-Xiang Fu  3 ,  Chun-Xia Zeng  3 ,  Lin Zhou  1 ,  Mei-Fen Bao  2 ,  Xiang-Hai Cai  2
Affiliations
  • 1. a College of Horticulture and Landscape, Yunnan Agriculture University , Kunming 650201 , China.
  • 2. b State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
  • 3. c Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
PMID: 26207974 DOI: 10.1080/10286020.2015.1057575
Abstract

HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight Lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human Cancer cell lines, HeLa, SGC-7901 gastric Cancer, and A-549 lung Cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.

Keywords
3′-methoxy-N-demethylrocaglamide; 4′-O-demethyl-deacetylaglaxiflorin A; Aglaia odorata; Meliaceae; cytotoxicity.
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