Kadcoccinic Acids A-J, Triterpene Acids from Kadsura coccinea

  • J Nat Prod. 2015 Aug 28;78(8):2067-73. doi: 10.1021/acs.jnatprod.5b00392.
Cheng-Qin Liang  1  2  3 ,  Yi-Ming Shi  1 ,  Wei-Guang Wang  1 ,  Zheng-Xi Hu  1 ,  Yan Li  1 ,  Yong-Tang Zheng  4 ,  Xiao-Nian Li  1 ,  Xue Du  1 ,  Jian-Xin Pu  1 ,  Wei-Lie Xiao  1 ,  Hong-Bin Zhang  3 ,  Han-Dong Sun  1
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • 2. Guilin Medical University , Guilin 541004, Guangxi, People's Republic of China.
  • 3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091, Yunnan, People's Republic of China.
  • 4. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650223, Yunnan, People's Republic of China.
PMID: 26214125 DOI: 10.1021/acs.jnatprod.5b00392
Abstract

Eleven triterpene acids including 10 new compounds (kadcoccinic acids A-J, 1-10) were isolated from the stems of Kadsura coccinea. Except for 10, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds 1 and 2 are the first examples of 2,3-seco-6/6/5/6-fused Tetracyclic Triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods. Additionally, the absolute configuration of 3 was determined by single-crystal X-ray diffraction. Several of the compounds isolated were tested for their anti-HIV-1 and cytotoxic activities.

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