Two new 13,14:14,15-disecopregnane-type compounds from the roots of Cynanchum paniculatum

  • J Asian Nat Prod Res. 2016;18(4):339-43. doi: 10.1080/10286020.2015.1080246.
Dan Zhao  1  2 ,  Hai-Feng Wang  1  2 ,  Gang Chen  1  2 ,  Yi-Peng Li  3 ,  Hui-Ming Hua  1  2 ,  Yue-Hu Pei  1  2
Affiliations
  • 1. a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • 2. b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • 3. c Yangtze River Pharmaceutical Group Pharmaceutical Co., Shanghai Haini , Shanghai 201318 , China.
PMID: 26465069 DOI: 10.1080/10286020.2015.1080246
Abstract

Two new 13,14:14,15-disecopregnane-type compounds glaucogenin F (1), glaucogenin F 3-O-β-D-oleandropyranoside (2), together with three known compounds cynapanoside A (3), cynatratoside A (4), and neocynapanogenin F 3-O-β-D-oleandropyranoside (5) were isolated from the 95% ethanol extract of the roots of Cynanchum paniculatum. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HRESIMS and NOESY.

Keywords
13,14:14,15-disecopregnane; Asclepiadaceae; Cynanchum paniculatum; glaucogenin F.
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