The pharmacology and therapeutic potential of (-)-huperzine A

  • J Exp Pharmacol. 2012 Sep 5;4:113-23. doi: 10.2147/JEP.S27084.
Maung Kyaw Moe Tun  1 ,  Seth B Herzon  1
Affiliations
  • 1. Department of Chemistry, Yale University, New Haven, CT, USA.
PMID: 27186124 DOI: 10.2147/JEP.S27084
Abstract

(-)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (-)-huperzine A (1). Synthetic studies of (-)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.

Keywords
Alzheimer’s; NMDA; natural products; neurodegeneration; synthesis.
Products