Halogenated Sesquiterpenoids from the Red Alga Laurencia tristicha Collected in Taiwan

  • J Nat Prod. 2016 Sep 23;79(9):2315-23. doi: 10.1021/acs.jnatprod.6b00452.
Jia-Yu Chen ,  Chiung-Yao Huang ,  Yun-Sheng Lin  1 ,  Tsong-Long Hwang  2 ,  Wei-Lung Wang  3 ,  Shu-Fen Chiou ,  Jyh-Horng Sheu  4  5
Affiliations
  • 1. Department of Biological Science & Technology, Mei Ho University , Pingtung 912, Taiwan.
  • 2. Graduate Institute of Natural Products, College of Medicine, Chang Gung University ; Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology; and Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
  • 3. Department of Biology, National Changhua University of Education , Changhua 500, Taiwan.
  • 4. Institute of Natural Products, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
  • 5. Department of Medical Research, China Medical University Hospital, China Medical University , Taichung 404, Taiwan.
PMID: 27536968 DOI: 10.1021/acs.jnatprod.6b00452
Abstract

Chemical investigation of the red alga Laurencia tristicha led to the discovery of eight new halogenated chamigrane-type sesquiterpenoids (1-8) and one new bromocuparane-type sesquiterpene (9), along with nine known related metabolites (10-18). Their structures were elucidated on the basis of extensive spectroscopic analyses, and the absolute configurations of 1-8 were proposed by comparison to the biosynthetically related known compound 12. Cytotoxicity, Antibacterial, and anti-inflammatory activities of these isolates were also investigated. The results showed that compound 11 exhibited good Antibacterial activity against Serratia marcescens compared to the positive control ampicillin at a dosage of 100 μg/disk. Compound 17 showed strong inhibition toward Elastase release generation at 10 μM.