Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

  • Bioorg Med Chem Lett. 2016 Oct 15;26(20):4966-4969. doi: 10.1016/j.bmcl.2016.09.007.
Ta-Yuan Whuang  1 ,  Wen-Cheng Tsai  2 ,  Nan-Fu Chen  3 ,  Zhi-Cheng Chen  4 ,  Kuan-Hao Tsui  5 ,  Zhi-Hong Wen  6 ,  Yin-Di Su  7 ,  Yu-Chia Chang  8 ,  Yu-Hsin Chen  9 ,  Mei-Chin Lu  1 ,  Lee-Shing Fang  10 ,  Jih-Jung Chen  11 ,  Tung-Ying Wu  12 ,  Yang-Chang Wu  13 ,  Ping-Jyun Sung  14
Affiliations
  • 1. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
  • 2. Medicine Department, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 833, Taiwan.
  • 3. Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
  • 4. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
  • 5. Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; Department of Obstetrics and Gynecology and Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
  • 6. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
  • 7. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
  • 8. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
  • 9. National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
  • 10. Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan.
  • 11. Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
  • 12. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
  • 13. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: [email protected].
  • 14. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: [email protected].
PMID: 27623548 DOI: 10.1016/j.bmcl.2016.09.007
Abstract

Columnaristerol A (1), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines.

Keywords
19-Norsterol; Columnaristerol; Cytotoxicity; Nephthea columnaris.