Cuspidate A, new anti-fungal triterpenoid saponin from Lepidagathis cuspidata

  • Nat Prod Res. 2017 Apr;31(7):773-779. doi: 10.1080/14786419.2016.1244192.
Rajeev Rattan  1 ,  Bharat Inder Fozdar  2 ,  Veena Gautam  1 ,  Ritika Sharma  3  4 ,  Dinesh Kumar  3  4 ,  Upendra Sharma  3  4
Affiliations
  • 1. a Department of Chemistry, Government Post Graduate College Dhaliara , Himachal Pradesh University , Shimla , India.
  • 2. b Department of Chemistry, School of Sciences , Indira Gandhi National Open University , New Delhi , India.
  • 3. c Natural Product Chemistry and Process Development Division , CSIR-Institute of Himalayan Bioresource Technology , Palampur , India.
  • 4. d CSIR , Academy of Scientific and Innovative Research , New Delhi , India.
PMID: 27827543 DOI: 10.1080/14786419.2016.1244192
Abstract

One new triterpenoid saponin named cuspidate A (1) along with a known oleanane-based triterpenoid saponin clemontanoside-C were isolated from the roots of Lepidagathis cuspidata. The structure of new compound (1) was established after detailed analysis of spectroscopic data including 1D and 2D NMR spectra. This is the first report on clemontanoside-C from this genus. These saponins were found to be effective against the selected Fungal strains Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, Aspergillus fumigates. Compound 1 showed better activity, comparable to the synthetic drug, while compound 2 showed a moderate effect against all studied Fungal strains.

Keywords
Lepidagathis cuspidata; anti-fungal; triterpenoid saponins.
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