Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂

  • Mar Drugs. 2016 Nov 25;14(12):217. doi: 10.3390/md14120217.
Hongju Liu  1  2 ,  Senhua Chen  3 ,  Weiyang Liu  4 ,  Yayue Liu  5 ,  Xishan Huang  6 ,  Zhigang She  7  8
Affiliations
  • 1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. [email protected].
  • 2. School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. [email protected].
  • 3. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. [email protected].
  • 4. School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. [email protected].
  • 5. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. [email protected].
  • 6. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. [email protected].
  • 7. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China. [email protected].
  • 8. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China. [email protected].
PMID: 27897975 DOI: 10.3390/md14120217
Abstract

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known Xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 μg/mL.

Keywords
Penicillium sp.; immunosuppressive activity; marine fungus; polyketides.
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