A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications

  • Chemistry. 2017 Jul 21;23(41):9872-9878. doi: 10.1002/chem.201701124.
Shahi Imam Reja  1 ,  Neetu Sharma  1 ,  Muskan Gupta  2 ,  Payal Bajaj  2 ,  Vandana Bhalla  1 ,  Ripu D Parihar  3 ,  Puja Ohri  3 ,  Gurcharan Kaur  2 ,  Manoj Kumar  1
Affiliations
  • 1. Department of Chemistry, UGC Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, India.
  • 2. Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
  • 3. Department of Zoology, Guru Nanak Dev University, Amritsar, India.
PMID: 28474839 DOI: 10.1002/chem.201701124
Abstract

A fluorescein-based fluorescent probe has been designed and synthesised that selectively detects H2 S in aqueous medium, among various analytes tested. This fluorescein-based fluorescent probe has also been successfully utilised for real-time imaging of exo- and endogenously produced H2 S in Cancer cells and normal cells. Moreover, the probe can also detect H2 S in the rat brain hippocampus at variable depths and in living nematodes.

Keywords
cancer; fluorescence; hydrogen sulfide; imaging; sensors.
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