Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca

  • J Nat Prod. 2018 Apr 27;81(4):1079-1083. doi: 10.1021/acs.jnatprod.7b00992.
Rohitesh Kumar  1 ,  Sandra Duffy  1 ,  Vicky M Avery  1 ,  Anthony R Carroll  1 ,  Rohan A Davis  1
Affiliations
  • 1. Griffith Institute for Drug Discovery, Griffith University , Brisbane , QLD 4111 , Australia.
PMID: 29533611 DOI: 10.1021/acs.jnatprod.7b00992
Abstract

Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline-serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.