Calcium carbonate-methylene blue nanohybrids for photodynamic therapy and ultrasound imaging

  • Sci China Life Sci. 2018 Apr;61(4):483-491. doi: 10.1007/s11427-017-9260-1.
Weili Fan  1  2 ,  Yu Qi  1  2 ,  Ranran Wang  1  2 ,  Chen Xu  1  2 ,  Nana Zhao  3  4 ,  Fu-Jian Xu  1  2
Affiliations
  • 1. Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing, China.
  • 2. Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
  • 3. Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology), Ministry of Education, Beijing, China. [email protected].
  • 4. Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China. [email protected].
PMID: 29546670 DOI: 10.1007/s11427-017-9260-1
Abstract

Photodynamic therapy plays an important role in Cancer treatment. In this work, methylene blue (MB)-embedded calcium carbonate nanorods (CaCO3-MB NRs) have been synthesized for pH-responsive photodynamic therapy and ultrasound imaging. The morphology of CaCO3-MB NRs can be controlled by modulating the concentration of Na2CO3 aqueous solution. The generation of effective Reactive Oxygen Species (ROS) were confirmed by 1,3-diphenylisobenzofuran (DPBF) probe. Both photodynamic therapy performance and echogenic performance of CaCO3-MB NRs were investigated to confirm the feasibility of CaCO3-MB nanohybrids for ultrasound image-guided photodynamic therapy.

Keywords
CaCO3-MB NRs; degradation; pH-responsive; photodynamic therapy; ultrasound imaging.
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