A new indole-type alkaloid from the roots of Clematis florida var. plena

  • Nat Prod Res. 2019 Oct;33(20):2925-2931. doi: 10.1080/14786419.2018.1510396.
Kai-Hui Sun  1 ,  Xin-Hua Ma  1 ,  Xian-Ming Zeng  1 ,  Zhong-Yue Lin  1 ,  Yu-Mei Cai  1 ,  Hai-Tao Zhang  1 ,  Xiao-Yan Lin  1 ,  Shi-Biao Feng  1 ,  Tian-Hua Zhong  2 ,  Yong-Hong Zhang  1
Affiliations
  • 1. a Key Laboratory of Natural Drug Pharmacology in Fujian Province, School of Pharmacy, Fujian Medical University , Fuzhou , P. R. China.
  • 2. b Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration , Xiamen , P. R. China.
PMID: 30518257 DOI: 10.1080/14786419.2018.1510396
Abstract

One new indole-type alkaloid, α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranosyl 6-methoxy-3-indolecarbonate (1), together with three known Alkaloids (2-4), one aromatic acid (5) and five known saponins (6-10), was isolated from the roots of Clematis florida var. plena. Their structures were established by NMR spectroscopic analysis and acid hydrolysis. In in vivo anti-inflammatory activity, n-butanol extract was found to be potent against ear edema in mice, with inhibition rate of 48.7% at a dose of 800 mg/kg. Furthermore, compounds 8 and 9 obtained from the n-butanol extract exhibited significant anti-inflammatory activities with inhibition rates of 50.9% and 54.7% at a dose of 200 mg/kg.

Keywords
alkaloid; anti-inflammatory; saponins.
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