Phenolic constituents with neuroprotective activities from Hypericum wightianum

  • Phytochemistry. 2019 Sep:165:112049. doi: 10.1016/j.phytochem.2019.112049.
Ling Yang  1 ,  Zi-Ming Wang  2 ,  Yun Wang  2 ,  Rong-Sheng Li  2 ,  Fei Wang  3 ,  Kou Wang  4
Affiliations
  • 1. School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China; Tongren Polytechnic College, Guizhou, 554300, PR China.
  • 2. School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China.
  • 3. BioBioPha Co., Ltd., Kunming 650201, PR China. Electronic address: [email protected].
  • 4. School of Pharmacy and Yunnan Key Laboratory of Natural Medicine Pharmacology, Kunming Medical University, Kunming, 650500, PR China. Electronic address: [email protected].
PMID: 31229788 DOI: 10.1016/j.phytochem.2019.112049
Abstract

Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole Plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM.

Keywords
Benzophenone glycosides; Depsidone; Flavone derivative; Hypericaceae; Hypericum wightianum wall. ex wight et Arn.; Neuroprotective activity.
Products