Novel macrocyclic antibiotics: megovalicins A, B, C, D, G and H. I. Screening of antibiotics-producing myxobacteria and production of megovalicins

  • J Antibiot (Tokyo). 1988 Apr;41(4):433-8. doi: 10.7164/antibiotics.41.433.
S Miyashiro  1 ,  S Yamanaka ,  S Takayama ,  H Shibai
Affiliations
  • 1. Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
PMID: 3131289 DOI: 10.7164/antibiotics.41.433
Abstract

New Antibiotics belonging to macrocyclic were discovered and named megovalicins A, B, C, D, G and H. The Antibiotics were accumulated endogeneously by a newly isolated myxobacterium identified as Myxococcus flavescens. Tank culture of the bacterium for 4 days gave 8.8 g cells/liter on a wet basis, and 4.8, 7.1, 20.0, 0.4, 3.75 and 15.0 micrograms of megovalicins A, B, C, D, G and H respectively were obtained from 1 g wet cells.

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