Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis
- Nat Prod Res. 2021 Aug;35(16):2707-2714. doi: 10.1080/14786419.2019.1666383.
- 1. Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei, Taiwan.
- 2. Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
- 3. Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan.
- 4. Taitung District Agricultural Research and Extension Station, Council of Agriculture, Taitung, Taiwan.
- 5. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-β-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2 D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC50 5.41 ∼ 11.28 μM. Compounds 3, 4, and 7 (IC50 8.42 ∼ 19.74 μM) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines.
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Cat. No.Product NameDescriptionTargetResearch Area
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target: DNA/RNA SynthesisResearch Areas: Metabolic Disease
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