Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

  • J Nat Prod. 2020 Feb 28;83(2):481-488. doi: 10.1021/acs.jnatprod.9b01147.
Keitaro Iwasaki  1 ,  Arihiro Iwasaki  1 ,  Shimpei Sumimoto  1 ,  Teruhiko Matsubara  2 ,  Toshinori Sato  2 ,  Tomoyoshi Nozaki  3 ,  Yumiko Saito-Nakano  4 ,  Kiyotake Suenaga  1
Affiliations
  • 1. Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • 2. Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
  • 3. Department of Biomedical Chemistry, Graduate School of Medicine , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-0033 , Japan.
  • 4. Department of Parasitology , National Institute of Infectious Diseases , 1-23-1 Toyama , Shinjuku-ku, Tokyo 162-8640 , Japan.
PMID: 32040324 DOI: 10.1021/acs.jnatprod.9b01147
Abstract

An antimalarial Lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human Cancer cell lines at 10 μM.