A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging

  • Anal Chem. 2020 Apr 7;92(7):5064-5072. doi: 10.1021/acs.analchem.9b05435.
Tongliang Zhou ,  Junda Wang ,  Jiamin Xu ,  Cangxin Zheng ,  Yan Niu ,  Chao Wang ,  Fengrong Xu ,  Lan Yuan ,  Xin Zhao ,  Lei Liang ,  Ping Xu
PMID: 32122120 DOI: 10.1021/acs.analchem.9b05435
Abstract

On the basis of the pyridazinone scaffold and photoinduced electron transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, PYSNO, with high sensitivity and selectivity. PYSNO exhibited a rapid response to both exogenous and endogenous NO. This probe can also be used in tracking and investigating NO generation in animal tissue. In the myocardial fibrosis model for mice, PYSNO exhibited a powerful imaging property in vivo as a result of unravelling the progressive relationship between the generation of myocardial NO and the occurrence of myocardial fibrosis.

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