Isolation and characterization of two new chroman-4-ones from the endophytic fungus Penicillium chrysogenum obtained from Eucommia ulmoides Oliver

  • Nat Prod Res. 2022 Jul;36(13):3297-3302. doi: 10.1080/14786419.2020.1855161.
Sheng-Yue Liu  1 ,  Li-Zhi Wang  1 ,  Yue-Fei Wang  1 ,  Lin Li  1 ,  Guo-Ying Han  1 ,  Bing-Yang Zhang  1 ,  Ying Guo  2 ,  Yong-Zhi He  1 ,  Shi-Ming Fang  1 ,  Han Zhang  1
Affiliations
  • 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
  • 2. Department of Neurology, Tianjin Nankai Hospital, Tianjin, China.
PMID: 33930984 DOI: 10.1080/14786419.2020.1855161
Abstract

Two new chroman-4-ones penicichromanone A (1) and penicichromanone B (2), together with three known compounds conioxepinol C (3), emodin (4) and moniliphenone (5), were obtained from the endophytic fungus Penicillium chrysogenum, which was isolated from the bark of Eucommia ulmoides Oliver. The structures of 1 and 2 were elucidated by detailed analysis of HRESIMS, 1D/2D NMR and ECD spectra. All the compounds were evaluated for their anti-inflammatory activities using HEK293 cells, and compounds 1, 3, 4 and 5 exhibited significant inhibitory effects on TNF-α-stimulated NF-κB activation.

Keywords
Eucommia ulmoides Oliver; NF-κB; Penicillium chrysogenum; chroman-4-ones.
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