Zinc delivery system constructed from food-borne nanoparticles derived from Undaria pinnatifida

  • Food Funct. 2021 Sep 20;12(18):8626-8634. doi: 10.1039/d1fo01852c.
Fengzhi Qiao  1  2  3 ,  Xiaoting Yu  1  2  3 ,  Shanshan Tie  1  2  3 ,  Yannan Chen  1  2  3 ,  Shuai Hou  1  2  3 ,  Mingqian Tan  1  2  3
Affiliations
  • 1. Academy of Food Interdisciplinary Science, Food Science and Technology, Dalian Polytechnic University, Qinggongyuan1, Ganjingzi District, Dalian 116034, Liaoning, China. [email protected].
  • 2. National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
  • 3. Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, Liaoning, China.
PMID: 34346455 DOI: 10.1039/d1fo01852c
Abstract

Food-borne nanoparticles from Undaria pinnatifida (UPFNs) were prepared and successfully applied as nanocarriers for microelement zinc delivery. UPFNs were spherical nanoparticles with average sizes of about 4.07 ± 1.09 nm, which chelated with zinc ions through amino nitrogen and carboxyl oxygen atoms as characterized by X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and 1H nuclear magnetic resonance spectroscopy. Thermodynamic analysis revealed that the overall chelation process between UPFNs and zinc ions was a spontaneous enthalpy-driven endothermic reaction. Compared to zinc sulfate, UPFN-Zn2+ showed higher solubility both in phytic acid solution and the process of gastrointestinal digestion. Meanwhile, no obvious cytotoxicity was found in UPFNs and UPFN-Zn2+. Specifically, UPFN-Zn2+ could successfully rescue cell viability, DNA replication activity and restore cell proliferation ability in zinc-deficient cells induced by a specific zinc chelator TPEN. Overall, UPFNs might serve as efficient, stable, and safe nanocarriers for zinc delivery.

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