Novel Harziane Diterpenes from Deep-Sea Sediment Fungus Trichoderma sp. SCSIOW21 and Their Potential Anti-Inflammatory Effects

  • Mar Drugs. 2021 Dec 1;19(12):689. doi: 10.3390/md19120689.
Hongxu Li  1  2 ,  Xinyi Liu  1 ,  Xiaofan Li  1 ,  Zhangli Hu  1  2 ,  Liyan Wang  1
Affiliations
  • 1. Shenzhen Key Laboratory of Marine Bioresource and Eco-Environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
  • 2. Key Laboratory of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
PMID: 34940688 DOI: 10.3390/md19120689
Abstract

Five undescribed harziane-type diterpene derivatives, namely harzianol K (1), harzianol L (4), harzianol M (5), harzianol N (6), harzianol O (7), along with two known compounds, hazianol J (2) and harzianol A (3) were isolated from the deep-sea sediment-derived fungus Trichoderma sp. SCSIOW21. The relative configurations were determined by meticulous spectroscopic methods including 1D, 2D NMR spectroscopy, and HR-ESI-MS. The absolute configurations were established by the ECD curve calculations and the X-ray crystallographic analysis. These compounds (1, and 4-7) contributed to increasing the diversity of the caged harziane type diterpenes with highly congested skeleton characteristics. Harzianol J (2) exhibited a weak anti-inflammatory effect with 81.8% NO inhibition at 100 µM.

Keywords
NO inhibition; Trichoderma; harziane diterpenes.
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