Okilactomycin, a novel antibiotic produced by a Streptomyces species. I. Taxonomy, fermentation, isolation and characterization

  • J Antibiot (Tokyo). 1987 Nov;40(11):1475-82. doi: 10.7164/antibiotics.40.1475.
H Imai  1 ,  K Suzuki ,  M Morioka ,  Y Numasaki ,  S Kadota ,  K Nagai ,  T Sato ,  M Iwanami ,  T Saito
Affiliations
  • 1. Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
PMID: 3693116 DOI: 10.7164/antibiotics.40.1475
Abstract

Okilactomycin, a novel Antibiotic, was isolated from the culture filtrate of a strain of actinomycetes. The producing organism, strain YP-02908L, was identified as Streptomyces griseoflavus subsp. zamamiensis subsp. nov. The Antibiotic was extracted with ethyl acetate and purified by silica gel column chromatography. It was obtained as colorless prisms from a dichloromethane solution. It exhibited weak antimicrobial activity against Ehrlich ascites carcinoma in vivo. The apparent molecular formula of okilactomycin was determined as C24H32O6. It is a new member of the lactone group Antibiotics.

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