Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

  • Beilstein J Org Chem. 2023 Jun 7:19:789-799. doi: 10.3762/bjoc.19.59.
Yuan-Nan Yuan  1  2 ,  Jin-Qiang Li  2  3 ,  Hong-Bin Fang  2 ,  Shao-Jun Xing  3 ,  Yong-Ming Yan  2 ,  Yong-Xian Cheng  1  2
Affiliations
  • 1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China.
  • 2. Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, PR China.
  • 3. Department of Pathogen Biology, Health Science Center, Shenzhen University, Shenzhen 518060, PR China.
PMID: 37346495 DOI: 10.3762/bjoc.19.59
Abstract

Six new compounds, including a tetralone 1, two Xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse Pancreatic Cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.

Keywords
Kronopolites svenhedini (Verhoeff); arthropod; iNOS; non-peptide small molecules.
Products