Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation
- Mar Drugs. 2026 Mar 13;24(3):108. doi: 10.3390/md24030108.
- 1. Research Center for Deepsea Bioresources, Sanya 572025, China.
- 2. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- 3. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Nine new mycophenolic acid derivatives, penicacids O-W (1-9), two first-time reported natural products (10, 11), and five known compounds (12-16), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher's methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human Cancer cell lines and the IC50 values ranged from nM to μM levels. Compounds 5, 7-9 showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC50 values between 0.13 and 1.13 μM.
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Topoisomerase; ADC Payloads; AMPK; Autophagy; Apoptosis; HIV; HBV; Mitophagy; Antibiotic; Bacterial; Fluorescent Dye