beta-Oxidation of the coenzyme A esters of vaccenic, elaidic, and petroselaidic acids by rat heart mitochondria

Rates of beta-oxidation of the coenzyme A esters of vaccenic, elaidic, and petroselaidic acids as well as their respective cis isomers by rat heart mitochondria were measured and compared. At all concentrations studied, vaccenoyl-CoA was oxidized more rapidly than elaidoyl-CoA, but more slowly than oleoyl-CoA except at high substrate concentrations. All trans octadecenoyl-CoA esters were oxidized at a slower rate than their respective cis or saturated isomers. Oxidation rates decreased as the double bond approached the carboxyl-end.