Dihydromevinolin, a potent hypocholesterolemic metabolite produced by Aspergillus terreus

  • J Antibiot (Tokyo). 1981 May;34(5):507-12. doi: 10.7164/antibiotics.34.507.
G Albers-Schönberg ,  H Joshua ,  M B Lopez ,  O D Hensens ,  J P Springer ,  J Chen ,  S Ostrove ,  C H Hoffman ,  A W Alberts ,  A A Patchett
PMID: 7275832 DOI: 10.7164/antibiotics.34.507
Abstract

A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of Cholesterol synthesis in vivo in rats.

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