Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D

  • J Antibiot (Tokyo). 1995 Jan;48(1):5-11. doi: 10.7164/antibiotics.48.5.
X H Huang  1 ,  H Nishida ,  H Tomoda ,  N Tabata ,  K Shiomi ,  D J Yang ,  H Takayanagi ,  S Omura
Affiliations
  • 1. Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 7868389 DOI: 10.7164/antibiotics.48.5
Abstract

Structures of terpendoles A, B, C and D, novel acyl-CoA: cholesterol Acyltransferase (ACAT) inhibitors, were determined by spectroscopic studies. All terpendoles consist of diterpene and indole moieties in common. Terpendoles A, C and D possess an additional isoprenyl unit via oxygen atom(s) of their diterpene moieties. The relative stereochemistries of terpendoles C and D were confirmed by NOE experiments and X-ray crystallographic analysis.

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