In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic

  • Antimicrob Agents Chemother. 1993 Jul;37(7):1547-51. doi: 10.1128/AAC.37.7.1547.
M Minamimura  1 ,  Y Taniyama ,  E Inoue ,  S Mitsuhashi
Affiliations
  • 1. Episome Institute, Gunma, Japan.
PMID: 8363389 DOI: 10.1128/AAC.37.7.1547
Abstract

In in vitro susceptibility tests, the new penem CP-70,429 showed potent Antibacterial activity against gram-positive and gram-negative bacteria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,429 was stable to various types of beta-lactamases except for the enzyme from X. maltophilia and was 16- to 128-fold more active than the Other compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.

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