Antiviral activity of lignans and their glycosides from Justicia procumbens

  • Phytochemistry. 1996 Jun;42(3):713-7. doi: 10.1016/0031-9422(96)00024-6.
J Asano  1 ,  K Chiba ,  M Tada ,  T Yoshii
Affiliations
  • 1. Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Japan.
PMID: 8768323 DOI: 10.1016/0031-9422(96)00024-6
Abstract

Ten Antiviral lignans, seven known (justicidins A, B, C and D, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate) and three new compounds, justicidinosides A (justicidin C 6'-O-glucoside), B (justicidin A 6'-O-glucoside) and C (justicidin B 6'-O-glucoside), were isolated from a methanolic extract of the aerial parts of Justicia procumbens var. leucantha. Justicidins A and B, diphyllin, diphyllin apioside and diphyllin apioside-5-acetate showed strong Antiviral activity (the MIC were less than 0.25 microgram ml-1, respectively) against vesicular stomatitis virus and low cytotoxicity (the MTC were larger than 31 micrograms ml-1, respectively) against cultured rabbit lung cells (RL-33).

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