Bioactive ent-kaurene diterpenoids from Annona senegalensis

  • J Nat Prod. 1996 Mar;59(3):301-3. doi: 10.1021/np9601566.
M O Fatope  1 ,  O T Audu ,  Y Takeda ,  L Zeng ,  G Shi ,  H Shimada ,  J L McLaughlin
Affiliations
  • 1. Department of Chemistry, Bayero University, Kano, Nigeria.
PMID: 8882434 DOI: 10.1021/np9601566
Abstract

Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1-4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast Cancer) cells (ED50 1.0 microgram/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate Cancer) cells but with weaker potencies (ED50 17-18 micrograms/mL). The structure of the new compound, 3, was deduced from spectral evidence.