Effects of alpha- and beta-galactosylated C2-ceramides on the immune system

  • J Med Chem. 1998 Feb 12;41(4):650-2. doi: 10.1021/jm970613v.
T Sakai  1 ,  H Ueno ,  T Natori ,  A Uchimura ,  K Motoki ,  Y Koezuka
Affiliations
  • 1. Pharmaceutical Research Laboratory, Kirin Brewery Company, Ltd., Gunma, Japan.
PMID: 9484513 DOI: 10.1021/jm970613v
Abstract

In contrast to the immunosuppressive effects of C2-ceramide (C2-Cer), alpha-galactosylceramides with ceramides having more than 10 carbons in fatty acid chains have immunostimulatory activities. We therefore synthesized alpha- and beta-galactosylated C2-Cers in order to examine their effects on the immune system. beta-Galactosylated C2-Cer and C2-Cer suppressed the allogeneic mixed leukocyte reaction (MLR) responses, but alpha-galactosylated C2-Cer stimulated the MLR response.

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