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Cat. No.: HY-170440A

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(R,R)-ATV2301

(R,R)-ATV2301 is the R,R isomer of ATV2301 (HY-170440). ATV2301 is an orally effective anti-influenza agent (H1N1 EC₅₀ is 1.88 nM, H3N2 EC₅₀ is 4.77 nM).

For research use only. We do not sell to patients.

CAS No.: 3049172-61-1
Formula: C₂₁H₁₇F₂N₃O₄S
Molecular Weight:445.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(R,R)-ATV2301 Chemical Structure

CAS No.: 3049172-61-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

(R,R)-ATV2301 is the R,R isomer of ATV2301 (HY-170440). ATV2301 is an orally effective anti-influenza agent (H1N1 EC₅₀ is 1.88 nM, H3N2 EC₅₀ is 4.77 nM)^[1].

Chemical Information

CAS No. 3049172-61-1
Molecular Weight 445.44
Formula C₂₁H₁₇F₂N₃O₄S
SMILES

OC1=C(C(N2[C@@]3([H])COCC2)=O)N(C=CC1=O)N3[C@H](C4=CC=C(F)C(F)=C4)C5=CC=CS5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (224.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

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Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2450 mL

11.2249 mL

22.4497 mL

5 mM

0.4490 mL

2.2450 mL

4.4899 mL

10 mM

0.2245 mL

1.1225 mL

2.2450 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yongzhi Chen, et al. Discovery of Novel Thiophene-Based Baloxavir Derivatives as Potent Cap-Dependent Endonuclease Inhibitors for Influenza Treatment. J Med Chem. 2024 Dec 26;67(24):22039-22054. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2450 mL	11.2249 mL	22.4497 mL	56.1243 mL
	5 mM	0.4490 mL	2.2450 mL	4.4899 mL	11.2249 mL
	10 mM	0.2245 mL	1.1225 mL	2.2450 mL	5.6124 mL
	15 mM	0.1497 mL	0.7483 mL	1.4966 mL	3.7416 mL
	20 mM	0.1122 mL	0.5612 mL	1.1225 mL	2.8062 mL
	25 mM	0.0898 mL	0.4490 mL	0.8980 mL	2.2450 mL
	30 mM	0.0748 mL	0.3742 mL	0.7483 mL	1.8708 mL
	40 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.4031 mL
	50 mM	0.0449 mL	0.2245 mL	0.4490 mL	1.1225 mL
	60 mM	0.0374 mL	0.1871 mL	0.3742 mL	0.9354 mL
	80 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.7016 mL
	100 mM	0.0224 mL	0.1122 mL	0.2245 mL	0.5612 mL

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MOQ

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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(R,R)-ATV2301

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(R,R)-ATV2301 Related Classifications

HY-170440A Related Classifications