Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc)

Adiponectin is a protein hormone and adipokine, which is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin has direct actions in liver, skeletal muscle, and the vasculature.Adiponectin exists in the circulation as varying molecular weight forms, produced by multimerization. Adiponectin enhances insulin sensitivity primarily by regulating fatty acid oxidation and inhibiting hepatic glucose production. It can also promote synaptic and memory function in the brain. Adiponectin stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilization and fatty-acid combustion. At the same time, it antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Adiponectin inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW^{[1][2][3][5][6][7]}.