Adipoq - adiponectin, C1Q and collagen domain containing Gene

Also Known as Ad; APN; Acdc; Adid; apM1; 30kDa; GBP28; adipo; Acrp30

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11450

Summary

Enables hormone activity and identical protein binding activity. Involved in several processes, including detection of oxidative stress; negative regulation of cold-induced thermogenesis; and regulation of protein serine/threonine kinase activity. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including brown fat cell differentiation; negative regulation of gluconeogenesis; and positive regulation of glucose import. Located in endoplasmic reticulum and extracellular space. Is expressed in several structures, including adipose tissue; axial musculature; gut; male reproductive gland or organ; and serum. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); non-alcoholic fatty liver disease; primary open angle glaucoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (Adiponectin, C1q and Collagen domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Adipoq Products (1)

mRNA Protein Name
NM_009605.5 NP_033735.3 adiponectin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
11479628 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
7592907 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12802337 MGI
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
20667975 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
12087086 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
acts upstream of or within cellular response to insulin stimulus IGI
IGI: Inferred from genetic interaction
17693256 MGI
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
19109165 MGI
involved in detection of oxidative stress IMP
IMP: Inferred from mutant phenotype
18431508 MGI
acts upstream of or within fatty acid beta-oxidation IMP
IMP: Inferred from mutant phenotype
12151381 MGI
acts upstream of or within fatty acid oxidation IDA
IDA: Inferred from direct assay
12802337 MGI
acts upstream of or within positive effect gene expression IDA
IDA: Inferred from direct assay
23015294 MGI
acts upstream of or within glucose homeostasis IDA
IDA: Inferred from direct assay
11479628 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12032136 MGI
acts upstream of or within glucose metabolic process IDA
IDA: Inferred from direct assay
11479628 MGI
acts upstream of or within glucose metabolic process IMP
IMP: Inferred from mutant phenotype
12032136 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18431508 MGI
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
19460854 MGI
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
19460854 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24531262 MGI
involved in negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
12021245 MGI
acts upstream of or within negative regulation of gluconeogenesis IDA
IDA: Inferred from direct assay
11479628 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
19109165 MGI
involved in negative regulation of metanephric mesenchymal cell migration IDA
IDA: Inferred from direct assay
19460854 MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19460854 MGI
involved in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IDA
IDA: Inferred from direct assay
19460854 MGI
acts upstream of or within positive regulation of D-glucose import IDA
IDA: Inferred from direct assay
12068289 MGI
involved in positive regulation of cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
18431508 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
12087086 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24531262 MGI
acts upstream of or within positive regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
12068289 MGI
involved in positive regulation of metanephric podocyte development IMP
IMP: Inferred from mutant phenotype
18431508 MGI
involved in positive regulation of renal albumin absorption IMP
IMP: Inferred from mutant phenotype
18431508 MGI
acts upstream of or within positive regulation of signal transduction IDA
IDA: Inferred from direct assay
12087086 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within response to glucose IDA
IDA: Inferred from direct assay
12068289 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
12032136 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10444069 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7592907 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adiponectin

  • 30 kDa adipocyte complement-related protein

  • adipocyte complement related protein

  • adipocyte complement-related 30 kDa protein

  • adipocyte, C1Q and collagen domain containing

  • adipocyte, C1q and collagen domain-containing protein

  • adipocyte-specific protei

Recombinant Adipoq Proteins

Cat. No. Product Name Accession Purity
HY-P7129 Adiponectin/Acrp30 Protein, Mouse (227a.a) Q60994 (V21-N247) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7358 Adiponectin/Acrp30 Protein, Mouse (V113M, 144a.a) Q60994 (K104-N247, V113M) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7461 Adiponectin/Acrp30 Protein, Mouse (HEK293, His) Q60994 (E18-N247) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78234 Adiponectin/Acrp30 Protein, Mouse (HEK293, Fc) Q60994 (E18-N247) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178447 PPARγ agonist 20 / Unkown
HY-RS00378 ADIPOQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17562 Adipoq Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24020 Adipoq Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adipoq NCBI NCBI:9370