2. Recombinant Proteins
  3. CD Antigens Receptor Proteins
  4. Stem Cell CD Proteins Platelet CD Proteins
  5. TPO-R/CD110
  6. C-MPL Protein, Rat (sf9, His)

C-MPL Protein, Rat (sf9, His)

Cat. No.: HY-P74243
Handling Instructions

The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (sf9, His) is the recombinant rat-derived C-MPL protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of C-MPL Protein, Rat (sf9, His) is 500 a.a., with molecular weight of ~55 kDa.

For research use only. We do not sell to patients.

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Description

The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (sf9, His) is the recombinant rat-derived C-MPL protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of C-MPL Protein, Rat (sf9, His) is 500 a.a., with molecular weight of ~55 kDa.
Background

The thrombopoietin receptor, also known as myeloproliferative leukemia protein or CD110 (differentiated cluster 110), is a protein encoded in humans by the myeloproliferative leukemia virus oncogene. C-MPL can activate thrombopoietin receptors, participate in bone marrow cell homeostasis, and platelet aggregation and actively regulate the process of platelet formation. C-MPL is involved in the phosphorylation of < B.AK /STAT/MAPK family proteins. C-MPL is a biomarker for thrombocytopenia[1][2][3].
Species

Rat
Source

Sf9 insect cells
Tag

C-His
Accession

XP_001072502 (M1-A500)
Gene ID
Molecular Construction
N-term
C-MPL (M1-A500)
Accession # XP_001072502
His
C-term
Synonyms
CD110; c-Mpl; MPL; MPLV; Thrombopoietin R; TPO-R
Molecular Weight

Approximately 55 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

C-MPL Protein, Rat (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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