2. Gene
  3. Mpl - MPL proto-oncogene, thrombopoietin receptor Gene

Mpl - MPL proto-oncogene, thrombopoietin receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 366455 | Gene type: protein coding

About Mpl

Primary_assembly 5: 131,973,895-131,986,797 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 186 orthologues, 7 paralogues and is associated with 19 phenotypes. Biased expression in Spleen (RPKM 1.6), Testes (RPKM 2.4) and 3 other tissues.

Summary

Predicted to enable Thrombopoietin Receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, Thrombopoietin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mpl Products(7)

mRNA Protein Name
XM_345572.10 XP_345573.5 thrombopoietin receptor isoform X4
XM_017593806.2 XP_017449295.1 thrombopoietin receptor isoform X3
XM_017593805.2 XP_017449294.1 thrombopoietin receptor isoform X2
XM_017593804.2 XP_017449293.1 thrombopoietin receptor isoform X1
XM_006238749.4 XP_006238811.1 thrombopoietin receptor isoform X7
XM_039111191.1 XP_038967119.1 thrombopoietin receptor isoform X5
XM_039111192.1 XP_038967120.1 thrombopoietin receptor isoform X6

Mpl Protein Structure

FN3

FN3: cl21522 (120 - 218)

FN3

FN3: cd00063 (496 - 585)

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  • 735 a.a.
Protein Preferred Names Protein Names

thrombopoietin receptor

myeloproliferative leukemia virus oncogene

Recombinant Mpl Proteins

Cat. No. Product Name Accession Purity
HY-P74243 C-MPL Protein, Rat (sf9, His) XP_001072502 (M1-A500) ≥95%
HY-P74244 C-MPL Protein, Rat (HEK293, Fc) XP_001072502.1 (Q22-A500） ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148748 Butyzamide Activator 99.62% Unkown
HY-112486 TA-316 98.19% Unkown
HY-144002 RIBI-529 / Unkown
HY-RS08616 MPL Human Pre-designed siRNA Set A / Unkown
HY-RS08617 Mpl Mouse Pre-designed siRNA Set A / Unkown
HY-RS08618 Mpl Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpl NCBI NCBI:4352
Macaca fascicularis Mpl NCBI NCBI:101864977
Mus musculus Mpl NCBI NCBI:17480
Susscrofa domestica Mpl NCBI
Macaca mulatta Mpl NCBI NCBI:723813