Mpl - MPL proto-oncogene, thrombopoietin receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 366455

About Mpl

Primary_assembly 5: 131,973,895-131,986,797 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 186 orthologues, 7 paralogues and is associated with 19 phenotypes. Biased expression in Spleen (RPKM 1.6), Testes (RPKM 2.4) and 3 other tissues.

Summary

Predicted to enable Thrombopoietin Receptor activity. Involved in several processes, including myeloid cell homeostasis; platelet aggregation; and positive regulation of platelet formation. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Used to study myelofibrosis. Biomarker of thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, Thrombopoietin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mpl Products (7)

mRNA Protein Name
XM_345572.10 XP_345573.5 thrombopoietin receptor isoform X4
XM_017593806.2 XP_017449295.1 thrombopoietin receptor isoform X3
XM_017593805.2 XP_017449294.1 thrombopoietin receptor isoform X2
XM_017593804.2 XP_017449293.1 thrombopoietin receptor isoform X1
XM_006238749.4 XP_006238811.1 thrombopoietin receptor isoform X7
XM_039111191.1 XP_038967119.1 thrombopoietin receptor isoform X5
XM_039111192.1 XP_038967120.1 thrombopoietin receptor isoform X6

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in basophil homeostasis IMP
IMP: Inferred from mutant phenotype
10606160 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
15642952 RGD
involved in eosinophil homeostasis IMP
IMP: Inferred from mutant phenotype
10606160 RGD
involved in monocyte homeostasis IMP
IMP: Inferred from mutant phenotype
10606160 RGD
involved in neutrophil homeostasis IMP
IMP: Inferred from mutant phenotype
10606160 RGD
involved in positive regulation of lymphocyte proliferation IMP
IMP: Inferred from mutant phenotype
10606160 RGD
involved in positive regulation of platelet formation IMP
IMP: Inferred from mutant phenotype
10606160 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
20467749 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15642952 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mpl Protein Structure

FN3

FN3: cl21522 (120 - 218)

FN3

FN3: cd00063 (496 - 585)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

thrombopoietin receptor

  • myeloproliferative leukemia virus oncogene

Recombinant Mpl Proteins

Cat. No. Product Name Accession Purity
HY-P74243 C-MPL Protein, Rat (sf9, His) A0A1W2Q6N1/XP_001072502.1 (Q22-A500) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74244 C-MPL Protein, Rat (HEK293, Fc) A0A1W2Q6N1/XP_001072502.1 (Q22-A500) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-125101A Rafutrombopag diolamine / Phase 4
HY-NP074 Maclura Pomifera Lectin / Phase 3

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148748 Butyzamide Activator 99.83% Unkown
HY-112486 TA-316 99.50% Unkown
HY-122620 Rafutrombopag (tautomerism) 98.33% Unkown
HY-112486G TA-316 (GMP) Agonist / Unkown
HY-148748G Butyzamide (GMP) Activator / Unkown
HY-145589 Rafutrombopag 95.29% Unkown
HY-144002 RIBI-529 / Unkown
HY-RS08616 MPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159671A 3D-Monophosphoryl Lipid (14) triethylamine Agonist / Unkown
HY-159671B 3D-Monophosphoryl Lipid (14) ammonium Agonist / Unkown
HY-159672 3D-Monophosphoryl Lipid (12,16) Agonist / Unkown
HY-159672A 3D-Monophosphoryl Lipid (12,16) free acid Agonist / Unkown
HY-159672B 3D-Monophosphoryl Lipid (12,16) triethylamine Agonist / Unkown
HY-RS08617 Mpl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08618 Mpl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159671 3D-Monophosphoryl Lipid (14) Agonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990685 Romiplostim Agonist ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpl NCBI NCBI:4352