CNTN4/Contactin-4 Protein, Human (sf9, His)
Based on 1 Customer Validation
The CNTN4/Contactin-4 protein is a member of the contactin family and plays a key role in promoting cell surface interactions critical for nervous system development. It has proven neurite growth-promoting activity, assisting in the complex processes involved in neuronal growth. CNTN4/Contactin-4 Protein, Human (sf9, His) is the recombinant human-derived CNTN4/Contactin-4 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CNTN4/Contactin-4 protein is a member of the contactin family and plays a key role in promoting cell surface interactions critical for nervous system development. It has proven neurite growth-promoting activity, assisting in the complex processes involved in neuronal growth. CNTN4/Contactin-4 Protein, Human (sf9, His) is the recombinant human-derived CNTN4/Contactin-4 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Background
Contactin-4 (CNTN4) is a protein critically involved in mediating cell surface interactions essential for nervous system development. This multifunctional molecule exhibits neurite outgrowth-promoting activity, underscoring its role in facilitating the extension of neuronal processes. Additionally, CNTN4 may play a key role in synaptogenesis, the process of forming functional connections between neurons. The interaction of CNTN4 with PTPRG suggests potential involvement in modulating signaling pathways or cellular adhesion during neural development. The diverse functions attributed to Contactin-4, including neurite outgrowth promotion and potential contributions to synaptogenesis, highlight its importance in orchestrating intricate processes crucial for the establishment of functional neural circuits.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag C-His
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Accession
Q8IWV2-1 (D19-S1000)
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Molecular Construction
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N-term
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CNTN4 (D19-S1000)
Accession # Q8IWV2-1 -
His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
CNTN4; Contactin-4; Contactin 4; Axonal-Associated Cell Adhesion Molecule; BIG-2; Neural Cell Adhesion Protein BIG-2; Brain-Derived Immunoglobulin Superfamily Protein 2; AXCAM
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AA Sequence
DDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGS
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Predicted Molecular Mass
110 kDa
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Molecular Weight
Approximately 120-130 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM Tris, 300 mM NaCl, pH 8.5, 10% glycerol
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Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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